Masato Homma Selected Research

Flecainide (Tambocor)

6/2020	Utilizing physiologically based pharmacokinetic modeling to predict theoretically conceivable extreme elevation of serum flecainide concentration in an anuric hemodialysis patient with cirrhosis.
10/2016	β1-Adrenergic receptor Arg389Gly polymorphism affects the antiarrhythmic efficacy of flecainide in patients with coadministration of β-blockers.
8/2015	Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
7/2013	SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients.
11/2012	CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis.
7/2009	Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism.
10/2007	Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia.
11/2006	Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia.
1/2005	Assessment of serum flecainide trough levels in patients with tachyarrhythmia.
9/2004	Simultaneous determination of serum flecainide and its metabolites by using high performance liquid chromatography.

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Masato Homma Research Topics

Disease

13	Tachycardia (Tachyarrhythmias) 01/2022 - 08/2002
5	Liddle Syndrome 01/2021 - 10/2006
5	Anemia 01/2006 - 08/2002
4	Pain (Aches) 01/2021 - 12/2005
3	Breast Neoplasms (Breast Cancer) 12/2020 - 01/2009
3	Body Weight (Weight, Body) 08/2015 - 11/2006
2	Neoplasms (Cancer) 01/2021 - 12/2016
2	Fibrosis (Cirrhosis) 06/2020 - 01/2012
2	Drug-Related Side Effects and Adverse Reactions 01/2020 - 10/2017
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2018 - 11/2016
2	Atrial Fibrillation 11/2018 - 01/2017
2	Carcinoma (Carcinomatosis) 10/2017 - 10/2004
2	Liver Diseases (Liver Disease) 01/2016 - 01/2014
2	Hyperuricemia 01/2016 - 01/2014
2	Hepatitis C 01/2013 - 10/2004
2	Hypokalemia 07/2007 - 10/2006
2	Hemolytic Anemia 01/2006 - 10/2004
1	Hyperlipidemias (Hyperlipidemia) 01/2022
1	Colonic Neoplasms (Colon Cancer) 12/2021
1	Stomach Ulcer (Gastric Ulcer) 08/2021
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 05/2021
1	Aplastic Anemia (Anemia, Hypoplastic) 05/2021
1	Stomatitis 01/2021
1	Constipation 01/2021
1	Hypoalbuminemia 01/2021
1	Hematuria 11/2020
1	Compartment Syndromes 11/2020
1	Chronic Kidney Failure (Chronic Renal Failure) 06/2020
1	Wounds and Injuries (Trauma) 02/2020
1	Thyroid Neoplasms (Thyroid Cancer) 01/2020
1	Exanthema (Rash) 12/2018
1	Diarrhea 12/2018
1	Mucositis 10/2017
1	Arteriosclerosis Obliterans 01/2017
1	Heart Failure 01/2017
1	Vascular Diseases (Vascular Disease) 01/2017
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2017
1	Brain Neoplasms (Brain Tumor) 11/2016
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2016
1	Tumor Lysis Syndrome 01/2014
1	Hematologic Neoplasms (Hematological Malignancy) 01/2014

Drug/Important Bio-Agent (IBA)

12	Flecainide (Tambocor)FDA LinkGeneric 06/2020 - 08/2002
7	Pharmaceutical PreparationsIBA 01/2022 - 01/2005
5	Glycyrrhizic Acid (Glycyrrhizin)IBA 01/2021 - 10/2006
3	Tacrolimus (Prograf)FDA LinkGeneric 08/2021 - 08/2002
3	Proton Pump InhibitorsIBA 08/2021 - 10/2004
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 12/2018 - 11/2016
3	Ribavirin (Virazole)FDA LinkGeneric 01/2006 - 04/2004
2	1- (4- chlorobenzoyl)- 3- (2- (1H- imidazol- 1- yl)- 2- oxoethyl)- 5- methoxy- 2- methyl- 1H- indoleIBA 01/2021 - 10/2017
2	Oral SpraysIBA 01/2021 - 10/2017
2	Indomethacin (Indometacin)FDA LinkGeneric 01/2021 - 10/2017
2	Analgesics (Analgesic Drugs)IBA 01/2021 - 10/2017
2	Lapatinib (GW572016)FDA Link 12/2020 - 12/2016
2	Anti-Arrhythmia AgentsIBA 06/2020 - 10/2007
2	EnzymesIBA 11/2016 - 08/2002
2	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 07/2009 - 11/2006
2	Rabeprazole (Aciphex)FDA Link 01/2009 - 10/2004
2	Hemoglobins (Hemoglobin)IBA 01/2006 - 04/2004
2	InterferonsIBA 01/2006 - 04/2004
1	Triglycerides (Triacylglycerol)IBA 01/2022
1	LipidsIBA 01/2022
1	Lipoproteins (Lipoprotein)IBA 01/2022
1	Amiodarone (Amiodarona)FDA LinkGeneric 01/2022
1	Bevacizumab (Avastin)FDA Link 12/2021
1	Inosine Triphosphate (ITP)IBA 05/2021
1	Thrombopoietin ReceptorsIBA 05/2021
1	eltrombopag FDA Link 05/2021
1	BilirubinIBA 01/2021
1	5-hydroxypropafenoneIBA 12/2020
1	Propafenone (Rythmol)FDA LinkGeneric 12/2020
1	Creatine Kinase (Creatine Phosphokinase)IBA 11/2020
1	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 06/2020
1	Mexiletine (Mexitil)FDA LinkGeneric 06/2020
1	Nerve AgentsIBA 02/2020
1	Tamoxifen FDA LinkGeneric 01/2020
1	lenvatinibIBA 01/2020
1	Uremic ToxinsIBA 11/2018
1	indoxylIBA 11/2018
1	Warfarin (Coumadin)FDA LinkGeneric 01/2017
1	Tyrosine Kinase InhibitorsIBA 11/2016
1	ErbB Receptors (EGF Receptor)IBA 11/2016
1	Cytochrome P-450 CYP3AIBA 11/2016
1	Phenytoin (Dilantin)FDA LinkGeneric 11/2016
1	Therapeutic UsesIBA 01/2016
1	rasburicase (Elitek)FDA Link 01/2016
1	geniposideIBA 01/2016
1	Xanthine OxidaseIBA 01/2014
1	Febuxostat FDA Link 01/2014
1	Allopurinol (Remid)FDA LinkGeneric 01/2014
1	GuanosineIBA 01/2013
1	Nucleoside Transport Proteins (Nucleoside Transporter)IBA 01/2013
1	Cytochrome P-450 CYP1A2 InhibitorsIBA 01/2013

Therapy/Procedure

4	Therapeutics 10/2017 - 04/2004
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2014
2	Radiotherapy 01/2021 - 10/2017
2	Kampo Medicine (Kampo) 10/2017 - 01/2016
1	Aftercare (After-Treatment) 01/2021
1	Conservative Treatment 11/2020
1	Renal Dialysis (Hemodialysis) 06/2020
1	Catheter Ablation 11/2018